The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.

نویسندگان

  • Ana R Hornillo-Araujo
  • Adam J M Burrell
  • Miren K Aiertza
  • Takayuki Shibata
  • David M Hammond
  • Dolorès Edmont
  • Harry Adams
  • Geoffrey P Margison
  • David M Williams
چکیده

The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine are described. The crystal structures and pKa values of these and related O6-methylguanine analogues are reported. All compounds display higher pKa values than O6-methylguanine with the sulfur-containing analogues being the more basic and exhibiting higher stability in aqueous solution. In a standard substrate assay with the human repair protein O6-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 4 9  شماره 

صفحات  -

تاریخ انتشار 2006